Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Beck L; Karaplis AC; Amizuka N; Hewson AS; Ozawa H; Tenenhouse HS Proc Natl Acad Sci U S A, 95(9):5372-7 1998
Growth hormone normalizes renal 1,25-dihydroxyvitamin D3-24-hydroxylase gene expression but not Na+-phosphate cotransporter (Npt2) mRNA in phosphate-deprived Hyp mice. Roy S; Martel J; Tenenhouse HS J Bone Miner Res, 12(10):1672-80 1997
Osteocalcin production in primary osteoblast cultures derived from normal and Hyp mice.Carpenter TO; Moltz KC; Ellis B; Andreoli M; McCarthy TL; Centrella M; Bryan D; Gundberg CM Endocrinology, 139(1):35-43 1998
Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, gyro (Gy) mouse. Meyer RA Jr; Henley CM; Meyer MH; Morgan PL; McDonald AG; Mills C; Price DK. 1998Genomics, 48(3):289-95
cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone. Du L; Desbarats M; Viel J; Glorieux FH; Cawthorn C; Ecarot B Genomics 1996 36: 22-8
Comparison of the Ability of Recombinant Human Parathyroid Hormone, rhPTH-(1-84), and hPTH-(1-31)NH_[2] to Stimulate Femoral Trabecular Bone Growth in Ovariectomized Rats. Morley, P., Willick, G.E., Ross, V., MacLean, S., Barbier, J.-R., Isaacs, R.J., Ohannessian-Barry, L. Calcified Tissue International 1997 60:27-29
The molecular defect in the renal sodium-phosphate transporter expression pathway of Gyro (Gy) mice is distinct from that of hypophosphatemic (Hyp) mice. Collins JF, Ghishan FK. FASEB Journal 1996 May;10(7):751-9
Normal phosphate transport in cells from the S2 and S3 segments of Hyp-mouse proximal renal tubules. Nesbitt T, Byun JK, Drezner MK Endocrinology 1996 Mar;137(3):943-8
Femoral abnormalities and Vitamin D metabolism in X-Linked Hypophosphatemia (Hyp and Gy) mice. R.A. Meyer, Jr., M.H. Meyer, R.W. Gray, M.E. Bruns. J. Orthop. Res. 13:30-40. 1995.
Decreased transcription of the sodium-phosphate transporter gene in the hypophosphatemic mouse. Collins JF, Scheving LA, Ghishan FK. American Journal of Physiology 1995 Sep;269(3 Pt 2):F439-48
Effect of P(i) restriction on renal Na(+)-P(i) cotransporter mRNA and immunoreactive protein in X-linked Hyp mice. Tenenhouse HS, Martel J, Biber J, Murer H. American Journal of Physiology 1995 Jun;268(6 Pt 2):F1062-9
Sodium-phosphate transporter adaptation to dietary phosphate deprivation in normal and hypophosphatemic mice. Collins JF, Bulus N, Ghishan FK American Journal of Physiology 1995 Jun;268(6 Pt 1):G917-24
Bone-forming ability of 24R,25-dihydroxyvitamin D3 in the hypophosphatemic mouse. Yamate T, Tanaka H, Nagai Y, Yamato H, Taniguchi N, Nakamura T, Seino Y Journal of Bone & Mineral Research 1994 Dec;9(12):1967-74
Molecular cloning, functional expression, tissue distribution, and in situ hybridization of the renal sodium phosphate (Na+/P(i)) transporter in the control and hypophosphatemic mouse. Collins JF, Ghishan FK FASEB Journal 1994 Aug;8(11):862-8
X-linked hypophosphatemic Gy mice: renal tubular maximum for phosphate vs. brush-border transport after low-P diet. Thornton SW, Tenenhouse HS, Martel J, Bockian RW, Meyer MH, Meyer RA Jr American Journal of Physiology 1994 Feb;266(2 Pt 2):F309-15
Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived Hyp mice: a mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets. Roy S, Martel J, Ma S, Tenenhouse HS. Endocrinology 1994 Apr;134(4):1761-7
Phosphate transport by osteoblasts from X-linked hypophosphatemic mice. Ecarot B, Caverzasio J, Desbarats M, Bonjour JP, Glorieux FH American Journal of Physiology 1994 Jan;266(1 Pt 1):E33-8
Crosstransplantation of kidneys in normal an HYP mice.Evidence that the HYP mouse phenotype is unrelated to an intrinsic renal defect. Nesbitt-T, Coffman-TM, Grffits-R, Drezner MK. J. Clin Invest 1992 89(5): 1453-9
Determination of a molecular map position for HYP using a new interespecific backcross produce in vitro fertilization. Kay-G: Thakker-RV: Rastan-S. Genomics 1991 Nov; 11 (3) ; 651-7
Craniofacial abnormalities in mice with X-linked hypophosphatemia genes (HYP or GY). Shetty-NS, Meyer-RA Jr. Teratology 1991 oct: 44(4): 463-72
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